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Implementing An infection Prevention and Management Measures Reduces CRE in Vietnam | Blogs

Vietnam has tailored established an infection prevention and management (IPC) measures for limited-resource settings to assist cease the unfold of carbapenem-resistant Enterobacterales (CRE), recognized as an pressing antimicrobial resistance (AR) risk in CDC’s 2019 AR Threats Report. A CDC-supported initiative at The College Medical Heart Ho Chi Minh Metropolis (UMC) in Vietnam that used IPC high quality enchancment (QI) methods to cut back CRE colonization and an infection in a normal intensive care unit (ICU) demonstrates the optimistic influence that IPC actions can have on CRE prevention.

Healthcare worker in ppe in a medical setting
UMC IPC employees member demonstrates private protecting gear and a brand new space for caring for sufferers with CRE.

CRE are a kind of resistant micro organism which might be regarding as a result of they will unfold shortly in healthcare settings and trigger extreme, difficult-to-treat infections. Nevertheless, some individuals will also be colonized with CRE, which means the micro organism are alive and rising on or in an individual’s physique with out the particular person having signs. When somebody is colonized, they aren’t actively sick, however colonized people could also be extra more likely to develop CRE infections sooner or later, they usually can unknowingly unfold CRE to others in. IPC is crucial to stop the unfold of those micro organism in well being care settings.

Combating CRE with IPC Interventions

UMC was identified to have excessive prevalence of CRE. Seventy-seven p.c of normal ICU sufferers examined there in June 2019 had been discovered to be colonized or contaminated with CRE, and plenty of of those sufferers probably acquired the micro organism whereas within the hospital. With CDC’s help, the QI CRE prevention actions started in September 2019, with the objective to lower the variety of sufferers newly recognized with CRE an infection or colonization within the ICU by 50% over one yr. Key actions included:

  • Screening all ICU sufferers for CRE on admission and each 2 days
  • Isolating any affected person discovered to be contaminated or colonized with CRE
  • Establishing cohort areas within the healthcare facility to take care of CRE sufferers
  • Enhancing hand hygiene monitoring for healthcare suppliers
  • Enhancing environmental cleansing and monitoring practices
  • Coaching IPC and ICU employees on these actions

Implementing efficient IPC in resource-limited settings could be difficult for a lot of causes, together with poor hospital infrastructure, insufficient human and materials assets, and hospital overcrowding. Nevertheless, regardless of these challenges, charges of CRE an infection and colonization decreased enormously at UMC with the implementation of those IPC actions. Over the course of the year-long QI undertaking, circumstances of CRE infections and colonization decreased by 85%, from 15.0 circumstances/100 patient-days in September 2019 to 2.3 circumstances/100 patient-days in August 2020. These spectacular outcomes have been sustained within the years for the reason that undertaking ended. UMC has continued IPC interventions together with screening all ICU sufferers for CRE (decreased to weekly frequency) and maintained incidence of latest CRE circumstances between 2.0 and 4.0 circumstances/100 affected person days.

When prevalence of AR is excessive in a healthcare setting, healthcare employees might really feel powerless to combat this public well being risk. Nevertheless, UMC’s success exhibits that even within the face of excessive prevalence and restricted assets, dedication to implementing IPC finest practices may also help healthcare employees successfully shield sufferers within the battle in opposition to AR and assist save lives.

Motivated by their success, UMC, with continued CDC help, hopes to broaden these actions to extra ICUs within the hospital and to mentor different hospitals in Vietnam to have comparable success.

Increasing Success Globally

The teachings realized from Vietnam will even inform the work of CDC’s World Motion in Healthcare Community (GAIHN), a collaborative community of nations, establishments, and companions at world, regional, nationwide, and subnational ranges working to handle rising infectious illness threats in healthcare settings by means of fast detection, prevention, and response.

In 2019, AR infections are estimated to have killed not less than 1.27 million individuals worldwide and had been related to practically 5 million deaths, greater than both HIV or malaria. That very same yr, the World Well being Group declared AR to be one of many high 10 public well being threats dealing with humanity. Current research point out that the USA and different nations misplaced progress combating AR throughout the COVID-19 pandemic, which means that the issue continues to develop and evolve in all areas of the world.

The Antimicrobial Resistance Module of GAIHN (GAIHN-AR), part of CDC’s World Antimicrobial Laboratory and Response Community, makes use of an method much like UMC’s to guard sufferers and healthcare employees from crucial and rising AR threats. GAIHN-AR healthcare amenities collaborate with laboratory and IPC specialists from the native to the worldwide stage to detect AR organisms in healthcare settings, talk about detected threats, and reply by implementing IPC actions.

Be taught extra about CDC’s work to detect, forestall, and reply to AR globally.


Antimicrobial Resistance Collaborators. World burden of bacterial antimicrobial resistance in 2019: a scientific evaluation. 2022. Lancet, 399, pp. 629-655. DOI: 10.1016/S0140-6736(21)02724-0

Tran, D.M., Larsson, M., Olson, L., Hoang, N.T.B., Le, N.Ok., Khu, D.T.Ok., Nguyen, H.D., Vu, T.V., Trinh, T.H., Le, T.Q., Phan, P.T.T., Nguyen, B.G., Pham, N.H., Mai, B.H., Nguyen, T.V., Nguyen, P.T.Ok., Le, N.D., Huynh, T.M., Anh Thu, L.T., Thanh, T.C., Berglund, B., Nilsson, L.E., Bornefall, E., Tune, L.H., Hanberger, H. 2019. Excessive prevalence of colonisation with carbapenem-resistant Enterobacteriaceae amongst sufferers admitted to Vietnamese hospitals: Threat elements and burden of illness. Journal of An infection, 79(2), pp. 115-122. DOI: 10.1016/j.jinf.2019.05.013

Creator: Amber Vasquez, MD, MPH is a doctor of Inside Medication and Infectious Ailments. She is at the moment crew lead within the Worldwide An infection Management Program within the Division of Healthcare High quality Promotion on the U.S. Facilities for Illness Management and Prevention in Atlanta.

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